Platform

Gel4Med's Smart Materials Platform (SMP™) redefines the landscape of biomaterials with its innovative molecular LEGO approach. This nano-engineering method precisely crafts peptide-based materials that mimic endogenous extracellular matrices and proteins, overcoming the limitations of traditional tissue harvesting.

By replicating natural biological structures and functions, SMP™ delivers adaptable, therapeutic biomaterials that set new industry standards. In contrast, traditional biomaterials typically derived from biological or synthetic sources face significant challenges, including variability and limited functional integration.

Gel4Med overcomes these challenges through its novel Smart Materials Platform (SMP™) providing superior benefits.

A new category of biomaterials

SMP™ is a patented bioengineering approach to design a new category of materials that seamlessly interact with and guide human biology. These materials, while manufactured synthetically, are created from Gel4Med’s foundational self-assembling peptides that are made of amino acids- the naturally occurring “building blocks” of proteins.

Flexible biodesign

SMP™ utilizes Gel4Med’s self-assembling peptide technology- a unique capability of peptides to self-organize into 3D matrices and mimic the extracellular matrix found in human tissue. This allows for the creation of customized materials that emulate biological structures and exert therapeutic functions through precise molecular design of amino acids sequence.

Unprecedented customization and precision

SMP™ approach harnesses the principles of synthetic biology to meticulously design and engineer highly customizable materials. These biomaterials offer precise control over biological, chemical, and mechanical properties, empowering tailored solutions for diverse clinical needs in regenerative medicine and surgical applications.

Adaptable Form Factor

SMP™ offers a broad variety of form factors, including flowable, spray, film, and more, to better suit various clinical needs depending on the anatomic locations and characteristics of the target tissues/organs.^1,2

Antimicrobial Capability

Gel4Med’s self-assembling peptide technology enables fine-tuning of antimicrobial activity, providing selective toxicity against pathogens while ensuring excellent compatibility with the host tissues.^3,4

Controlled Delivery

SMP™ transforms the way that therapeutics from tiny molecules to big biomolecules, and even living cells and genetic material are delivered to the exact locations where they are most needed.⁵

Customizable Biodegradability

SMP™ enables customization and control of biodegradation rates of our biomaterials, which allows for either rapid degradation for short-term support or slow resorption for long-lasting therapeutic effects.

Biomechanical Tunability

Through the SMP™ approach, biomechanics of our materials can be customized to result in different material stiffness and strength, as well as allow for physical state transitions (solid to liquid to solid) upon application and removal of mechanical forces.

Stimuli Responsiveness

SMP™ enables the development of materials that can respond to environmental (light, electrical, mechanical forces) and physiological (pH, enzymes, redox potential) stimuli. This "on/off switch" capability allows for precise control over when and where the therapeutic effect is delivered.⁶

References

1. Levin et al. Biomimetic peptide self-assembly for functional materials. Nat Rev Chem. 2020; 2. Li et al. Peptide-based nanomaterials: Self-assembly, properties and applications. Bioact Mater. 2021; 3. Veiga et al. Arginine-rich self-assembling peptides as potent antibacterial gels. Biomaterials. 2012; 4. López Cascales et al. Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity. ACS Omega. 2018; 5. Karavasili and Fatouros. Self-assembling peptides as vectors for local drug delivery and tissue engineering applications. Adv Drug Deliv Rev. 2021; 6. Muet al. Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications. Bioact Mater. 2024

"Gel4Med is revolutionizing the field of regenerative medicine with its Smart Materials Platform. We are excited to support their mission to improve patient outcomes and change the industry as we know it."

Lindy Fishburne

Breakout Labs

Smart Materials Platform (SMP™)

A new category of biomaterials

Flexible biodesign

Unprecedented customization and precision

Adaptable Form Factor

Antimicrobial Capability

Controlled Delivery

Customizable Biodegradability

Biomechanical Tunability

Stimuli Responsiveness

References

Pipeline

Join us on the journey. We're actively looking for partnerships in biomaterials-based research, product development, and commercialization.

Our Collaborators

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